Effect of maternal age on pregnancy outcome in patients with structural heart disease / 中华妇产科杂志

ABSTRACT

Objective To analyze the effect of maternal age on pregnancy outcome in patients with structural heart disease. Methods Totally 986 patients diagnosed with structural heart disease who had their delivery at Renji Hospital from January 1st,2003 to December 31st,2016 were divided into 5 groups according to maternal age. Sixteen(1.6%)were in age group <20 years, 204(20.7%)were in age group 20-24 years,461(46.8%)were in age group 25-29 years,222(22.5%)was in age group 30-34 years and 83(8.4%)was in age group ≥35 years.The incidence of cardiac,obstetric and fetal complications among these groups were analyzed. Results Among the 986 patients with structural heart disease, 82(8.3%) experienced adverse cardiac events(some patients had more than 1 complication), including infective endocarditis(0.4%,4/986), malignant arrhythmia(3.3%, 33/986), heart failure(5.3%, 52/986), cardiac death(0.9%,9/986).The incidence of cardiac complications were respectively 12.5%,11.3%,4.8%,10.4% and 14.5% in each age group,with statistically significant differences when compared with one another(P=0.004). There was no statistically significant difference in the incidence of obstetric complications(P>0.05). The incidence of fetal complications in each group showed statistically significant differences(P=0.001);which was 25.0%,30.4%,24.1%,29.3% and 47.0% respectively. Conclusions Age group 25-29 years presented the lowest risk of cardiac complications and is potentially the optimal age for pregnancy and delivery.Age group<20 or≥35 years is at higher risk for cardiac complications. The highest rate of fetal complications is in age group≥35 years.