The Clinical Effects of Nicorandil during Percutaneous Coronary Intervention in Patients with Unstable Angina
Korean Circulation Journal
; : 322-327, 2005.
Article
en Ko
| WPRIM
| ID: wpr-72480
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: The purpose of the study was to evaluate the clinical effect of Nicorandil during percutaneous coronary intervention (PCI) in patients with unstable angina (UA). SUBJECTS AND METHODS: Two hundred patients (61+/-10 years, male 143) with UA were randomly assigned to two groups: intravenous Isosorbide dinitrate (Group I, n=100) and intravenous Nicorandil (Group II, n=100). PCI was performed 12-48 hours after infusion of the agents. The post-procedural cardiac enzymes, 6-month MACE (major adverse cardiac event) and left ventricular ejection fraction (LVEF) were compared between the two groups. RESULTS: Successful PCI was performed in 96 patients (Group I=54, Group II=42). Patients requiring either emergent coronary angiography, temporary pacemaker or platelet glycoprotein IIb/IIIa receptor blocker were excluded. No significant differences were observed between the two groups in terms of the clinical and coronary angiographic characteristics. The level of creatine kinase-MB was elevated in 9 (17%) and 6 patients (14%), troponin T in 16 (30%) and 6 (14%) and troponin I in 25 (46%) and 9 (21%) patients of Groups I and II, respectively, after the PCI. The elevation of all troponins was lower in Group II (28 vs. 10 patients, p=0.01). MACE developed in 9 (17%) and 5 (12%) patients of Groups I and II (p=NS), respectively, during the 6-month clinical follow-up. The LVEF was higher in Group II than in Group I on follow-up echocardiography (65.4+/-7.2% vs. 71.0+/-6.7%, p=0.003). CONCLUSION: Nicorandil may have a myocardial protective effect during PCI in patients with UA.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Volumen Sistólico
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Troponina
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Plaquetas
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Ecocardiografía
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Glicoproteínas
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Estudios de Seguimiento
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Angiografía Coronaria
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Nitroglicerina
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Angioplastia
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Troponina I
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Humans
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Male
Idioma:
Ko
Año:
2005
Tipo del documento:
Article