Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
Natural Product Sciences
; : 148-154, 2018.
Article
en En
| WPRIM
| ID: wpr-741625
Biblioteca responsable:
WPRO
ABSTRACT
Chronic oxidative stress due to the accumulation of reactive oxygen species (ROS) in neuronal cells ultimately leads to neurodegenerative diseases. The use of natural therapies for the prevention of ROS-induced cell damage and for the treatment of neurodegenerative disorders has shown promising results. In this study, we evaluated the neuroprotective effects of the ethyl acetate (EtOAc) fraction of A. Okamotoanum against the hydrogen peroxide (H₂O₂)-induced oxidative stress in C6 glial cells. Results show that cell viability was decreased in cells incubated with H₂O₂, whereas the addition of EtOAc fraction treatments in such cells significantly increased viability. The EtOAc fraction showed the highest inhibitory activity against ROS production and it also decreased the expressions of inflammatory proteins including cyclooxygenase-2, inducible nitric oxide synthase and interleukin-1β. Furthermore, the EtOAc fraction inhibited apoptosis by regulating the protein expressions cleaved caspase
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Supervivencia Celular
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Neuroglía
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Poli(ADP-Ribosa) Polimerasas
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Especies Reactivas de Oxígeno
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Apoptosis
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Estrés Oxidativo
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Fármacos Neuroprotectores
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Enfermedades Neurodegenerativas
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Acer
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Ciclooxigenasa 2
Idioma:
En
Año:
2018
Tipo del documento:
Article