Determination of fluoxetine hydrochloride by HPLC / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 58-59,82, 2015.
Article
en Zh
| WPRIM
| ID: wpr-790407
Biblioteca responsable:
WPRO
ABSTRACT
Objective To establish an HPLC method for assay determination of fluoxetine hydrochloride .Methods Agi‐lent Eclipse XDB‐C8 (4 .6 mm × 250 mm ,5μm) was used ,mobile phase was tetrahydrofuran‐methanol‐triethylamine buffer (to 10 ml of triethylamine in a 1 000 ml flask ,added 980 ml of water ,pH was adjust to 6.0 by phosphoric acid) (30:10:60) ,flow rate was 1 .0 ml/min ,detection wavelength was 227 nm ,injection volume was 10 μl ,column temperature was 25 ℃ .Results Linearity range was 55 .17‐165 .51 μg/ml (r= 0 .999 9) ,minimum detection limit was 0 .15 μg/ml ,accuracy was between 99.9%‐100 .0% ,repeatability RSD was 0 .1% (n=6) .Conclusion The method was accurate and reliable ,which could be ap‐plied for quality control of fluoxetine hydrochloride .
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Banco de datos:
WPRIM
Idioma:
Zh
Año:
2015
Tipo del documento:
Article