Effect and Mechanism of Modified Danzhi Xiaoyaosan in Treating Post-stroke Depression / 中国实验方剂学杂志

ABSTRACT

Objective: To observe the clinical efficiency of the liver soothing method(modified Danzhi Xiaoyaosan) in the treatment of post-stroke depression(PSD), and explore its mechanism.Method: A total of 148 patients with PSD were randomly divided into study group and control group, with 74 cases in each group. Control group received Escitalopram Oxalate, 10 mg·d-1. Study group received Shugan granule 3 g, twice a day, in addition to the therapy of control group. One course of treatment of 4 weeks. Hamilton depression scale (HAMD) score, neurotransmitter power, 5-hydroxytryptamine(5-HT), noradrenalin(NE) levels and inflammatory factors were compared between the two groups.Result: The clinical efficacy of study group was significantly better than that of control group(Z=2.97, Pχ2=4.40, PPPPPPPPα(TNF-α), interleukin-1 beta(IL-1β) and interleukin-6(IL-6) levels in both groups decreased in the process of treatment (Pα, IL-1β and IL-6 levels in study group were decreased more significantly than those in control group (PConclusion: Modified Danzhi Xiaoyaosan combined with traditional antidepressants has a more significant curative effect in the treatment of PSD. The mechanism may be related to the inhibition of the expressions of inflammatory factors. Further studies shall be conducted.