Neuroprotective Effect of Ginseng Total Saponins in Experimental Traumatic Brain Injury
Journal of Korean Medical Science
; : 291-296, 2005.
Article
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| WPRIM
| ID: wpr-8383
Biblioteca responsable:
WPRO
ABSTRACT
In the present study, we investigated whether ginseng total saponins (GTSs) protect hippocampal neurons after experimental traumatic brain injury (TBI) in rats. A moderate-grade TBI was made with the aid of a controlled cortical impact (CCI) device set at a velocity of 3.0 m/sec, a deformation of 3.0 mm, and a compression time of 0.2 sec at the right parietal area for adult male Sprague-Dawley rats. Shamoperated rats that underwent craniectomy without impact served as controls. GTSs (100 and 200 mg/kg) or saline was injected intraperitoneally into the rats immediately post-injury. Twenty-four hours after the injury, the rats underwent neurological evaluation. Contusion volume and the number of hippocampal neurons were calculated with apoptosis evaluated by TUNEL staining. 24 hr post-injury, salineinjected rats showed a significant loss of neuronal cells in the CA2 region of the right hippocampus (53.4%, p<0.05) and CA3 (34.6%, p<0.05) compared with contralateral hippocampal region, a significant increase in contusion volume (34 +/-8microliter), and significant increase in neurologic deficits compared with the GTSs groups. Treating rats with GTSs seemed to protect the CCI-induced neuronal loss in the hippocampus, decrease cortical contusion volume, and improve neurological deficits.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Saponinas
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Coloración y Etiquetado
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Lesiones Encefálicas
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Ratas Sprague-Dawley
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Fármacos Neuroprotectores
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Etiquetado Corte-Fin in Situ
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Panax
Límite:
Animals
Idioma:
En
Año:
2005
Tipo del documento:
Article