The diagnostic value of serum Golgi protein-73 in hepatocellular carcinoma / 肿瘤

ABSTRACT

Objective: To investigate the diagnostic value of serum Golgi protein-73 (GP73) in hepatocellular carcinoma (HCC). Methods: The peripheral serum samples from 504 individuals were collected, including 144 HCC patients, 50 cirrhotic patients, 100 hepatitis B patients, 84 hepatitis B virus carriers, 50 patients with other malignancies, 26 patients with benign liver tumor, and 50 healthy volunteers. The expression levels of serum GP73 and alpha-fetal protein (AFP) were detected by double antibody sandwich ELISA and electrochemiluminescence assay, respectvely. Results: The expression level of serum GP73 from the HCC patients was significantly higher than those from the other patient groups (P <0.05). When the cut-off value was determined as 64 ng/mL by the receiver operating characteristic (ROC) curve, the sensitivity and specificity of GP73 for the diagnosis of HCC were both higher than those of AFP (83.3% vs 72.2%; 88.3% vs 76.7%; both P <0.05). The sensitivity of GP73 in combination with serum AFP for the diagnosis of HCC was 94.4%. Conclusion: The sensitivity and specificity of serum GP73 for the diagnosis of HCC are higher than those of serum AFP. The rate of HCC diagnosis is increased by combined examination of serum GP73 and AFP. Copyright © 2012 by TUMOR.