Diagnostic Value of Noninvasive Biomarkers in Endoscopic Activity of Ulcerative Colitis / 胃肠病学

ABSTRACT

Background: Ulcerative colitis (UC) is characterized by a chronic intestinal inflammatory disease with relapsing-remitting course, therefore the evaluation of inflammatory activity is essential for defining reasonable therapy and predicting prognosis. Aims: To evaluate the diagnostic value of noninvasive biomarkers in assessing endoscopic activity of UC. Methods: A total of 56 patients with UC from August 2016 to March 2018 at Xiangyang Central Hospital were enrolled, and 25 patients with irritable bowel syndrome (IBS) were served as controls. Fecal calprotectin (FC) level was measured by ELISA. Clinical activity index (CAI) was assessed, and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were determined. Endoscopic activity was determined by Mayo score. Diagnostic value of noninvasive biomarkers in assessing endoscopic activity of UC was analyzed. Results: FC level was significantly higher in UC patients than in IBS patients (P<0.001). FC, CAI, CRP, ESR in active UC patients were significantly higher than those in remissive UC patients (P<0.001). Mayo score was correlated with FC (r=0.814), CAI (r=0.724), CRP (r=0.610), ESR (r=0.657) (P all <0.001). FC with a cutoff value of 200 μg/g had sensitivity of 92.3% and specificity of 94.1% for detecting endoscopic activity. Conclusions: Compared with CAI, CRP and ESR, FC can more effectively evaluate the endoscopic active inflammation in UC patients.