The regulation of miRNA in age-related macular degeneration / 中华眼底病杂志
Chinese Journal of Ocular Fundus Diseases
; (6): 560-564, 2020.
Article
en Zh
| WPRIM
| ID: wpr-871782
Biblioteca responsable:
WPRO
ABSTRACT
MiRNAs are stable small RNAs that are expressed abundantly in animals and plants. They can bind to the 3'-untranslated region of the target mRNA, and regulate its expression at the post-transcriptional level. The miRNAs' abnormal expression and its following abnormal biological regulation are closely related to the occurrence and development of age-related macular degeneration (AMD), including inflammatory response, oxidative stress injury, phagocytosis dysfunction and abnormal angiogenesis. Since the dysregulation of miR-155, miR-125b and miR-34a seems to play a more important role in AMD, these microRNAs may be expected to become the new biomarkers and therapeutic targets for AMD.
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1
Banco de datos:
WPRIM
Idioma:
Zh
Año:
2020
Tipo del documento:
Article