Research progress of circular RNA in oral squamous cell carcinoma / 中国医师杂志

ABSTRACT

Circular RNA (CircRNA) is an endogenous closed circular noncoding RNA widely existing in organisms. It has a variety of biological functions and the characteristics of stable structure, high conservation, tissue and developmental stage specificity. Studies have confirmed that CircRNA plays an important role in regulating tumor gene expression, including participating in the occurrence, development and metastasis of oral squamous cell carcinoma (OSCC). It has the potential to become a new biomarker for the diagnosis and prognosis of OSCC, and can be used as a potential target for the treatment of OSCC. This paper reviews the biological characteristics of CircRNA and its latest research status in the diagnosis, treatment and prognosis of OSCC.