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False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia

Borges, Moara Alves Santa Bárbara; Araújo Filho, João Alves de; Soares, Renata de Bastos Ascenço; Vidal, José Ernesto; Turchi, Marília Dalva.
Med. mycol. case rep ; 26: 64-66, Dec. 2019. ilus, tab
Artigo Inglês | SES-SP, SES SP - Instituto de Infectologia Emílio Ribas, SES-SP | ID: biblio-1025285
The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4=42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant
Biblioteca responsável: BR31.1
Localização: BR31.1; 2019_P-029
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