Association of IL-6, IL-10 and CXCL10 serum concentrations with visceral Kaposi's sarcoma in people living with HIV/AIDS
Lopes, Thaisa Regina Rocha; Gonçales, Juliana Prado; Silva Júnior, José Valter Joaquim; Lorena, Virgínia Maria Barros de; Toscano, Ana Luiza Castro Conde; Akamatsu, Sandra Mitie; Salles, Ângela Christina; Mendoza, Tânia Regina Tozetto; Morais, Viviane Martha Santos de; Coelho, Maria Rosângela Cunha Duarte.
Hum. immunol
; 81(1): 26-31, Jan. 2020. tab, ilus
Artigo
Inglês
| SES-SP, SES SP - Instituto de Infectologia Emílio Ribas, SES-SP | ID: biblio-1049267
Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), one of the most common cancers in people living with HIV/AIDS. It is believe that the course of both HIV and HHV-8 infection is associated with the imbalance of anti- and/or pro-inflammatory cytokines. Here, we evaluated the IL-6, TNF-α, IL-10, CCL2 and CXCL10 serum concentrations in HIV- and HIV/HHV-8 (without KS) individuals, and in patients with cutaneous or visceral AIDS-KS. Serum concentrations of IL-6, IL-10 and CXCL10 were significantly higher in the AIDS-KS group compared to HIV and HIV/HHV-8 individuals. Similarly, the concentrations of theses cytokines were higher in patients with visceral than in those with cutaneous AIDS-KS. The TNF-α concentration was significantly higher in the HIV group compared to HIV/HHV-8 (with and without KS) individuals, and CCL2 levels did not present significant difference among the groups. The HIV viral load was undetectable in all patients from the HIV and HIV/HHV-8 groups. On the other hand, in the AIDS-KS group, most patients had detectable HIV viral load. In this context, we believe that the cytokine levels in AIDS-KS may be result of a complex interaction between HIV, HHV-8 and immunity
Biblioteca responsável:
BR31.1
Localização: BR31.1; 2020_P-004
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