Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae
Microbial Genomics
; 4(3): 1-35, 2018. ilus
Article
em En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1064745
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Extensively drug-resistant Klebsiella pneumoniae (XDR-KP) infections cause high mortality and are disseminating globally. Identifying the genetic basis underpinning resistance allows for rapid diagnosis and treatment. XDR isolates sourced fromGreece and Brazil, including 19 polymyxin-resistant and five polymyxin-susceptible strains, were subjected to whole genomesequencing. Seventeen of the 19 polymyxin-resistant isolates harboured variations upstream or within mgrB. The mostcommon mutation identified was an insertion at nucleotide position 75 in mgrB via an ISKpn26-like element in the ST258lineage and ISKpn13 in one ST11 isolate. Three strains acquired an IS1 element upstream of mgrB and another strain had anISKpn25 insertion at 133 bp...
Texto completo:
1
Coleção SES:
Producao_cientifica
Base de dados:
SES-SP
/
SESSP-IDPCPROD
Assunto principal:
Polimixinas
/
Klebsiella pneumoniae
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article