Visceral fat and coronary artery calcification in patientswith chronic kidney disease
Cordeiro, Antonio Carlos; Quresh, Abdul Rashid; Lindholm, Bengt; Amparo, Fernanda Cassullo; Paladino Filho, Antonio Tito; Perini, Marcela; Lourenço, Fernanda Silvestre; Pinto, Ibraim Masciarelli Francisco; Amodeo, Celso; Carrero, Juan Jesús.
Nephrol. dial. transplant
; 28(supl 04): 152-159, 2013. ilus
Artigo
Inglês
| SES-SP, SES SP - Instituto Dante Pazzanese de Cardiologia, SES-SP | ID: biblio-1064917
Background. Abdominal fat is a metabolically active tissuewhich has been associated with cardiovascular events anddeath in chronic kidney disease (CKD) patients. We explorehere the association between surrogates of abdominal fat andcoronary artery calcium score (CACs).Methods. Cross-sectional analysis of 232 non-dialysisdependentCKD patients Stages 35 (median age 60 [25th75thpercentile 5267] years; 60% men). Visceral adipose tissue(VAT) and CACs were assessed by computed tomography. Surrogatesof abdominal fat included VAT and waist circumference(WC).Results. VAT was positively associated with CACs in univariateanalysis (ρ = 0.23). Across increasing VAT quartiles,patients were older, more often men and smokers. Althoughincreasing VAT quartiles associated with higher glomerular filtrationrate and leptin, better nutritional status (subjectiveglobal assessment) as well as larger muscle stores and strength,they were also more insulin resistant (HOMA-IR), dyslipidemicand inflamed (C-reactive protein and white blood cells).In addition, CACs were incrementally higher. Clinicallyevident coronary artery calcification (CACs ≥ 10 Agatston) was present in 63% of the patients. Both increased visceral fat(odd ratio 1.60 [95% CI 1.232.09] per standard deviation increase)and increased WC (1.05 [1.011.12] per cm increase),augmented the odds to present calcification. Such associationsremained statistically significant after extensive multivariateadjustment for confounders.Conclusions. Abdominal fat is associated with coronary arterycalcification in non-dialysis dependent CKD patients, supportingits potential role as a cardiovascular risk factor in uremia.
Biblioteca responsável:
BR79.1
Localização: BR79.1
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