A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population
s.l; s.n; 2002. 4 p. tab, graf.
Non-conventional
em En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1240944
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1", "_a": "08997/s"}]
ABSTRACT
A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.
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Coleção SES:
Acervo_geral
Base de dados:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Marcadores Genéticos
/
Mapeamento Cromossômico
/
Repetições de Microssatélites
/
Predisposição Genética para Doença
/
Genética Populacional
/
Índia
/
Hanseníase
/
Mycobacterium leprae
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Non-conventional