Placental Microparticles and MicroRNAs in Pregnant Women with Plasmodium falciparum or HIV Infection
PLos ONE
; 11(1): 1-17, jan 12, 2016. ilus, graf
Article
em En
| RSDM
| ID: biblio-1526873
Biblioteca responsável:
MZ1.1
ABSTRACT
During pregnancy, syncytiotrophoblast vesicles contribute to maternal tolerance towards the fetus, but also to pathologies such as pre-eclampsia. The aim of the study was to address whether Plasmodium falciparum and HIV infections in pregnancy affect the secretion, microRNA content and function of trophoblast microparticles. Methods:
Microparticles were isolated and characterized from 122 peripheral plasmas of Mozambican pregnant women, malaria- and/or HIV-infected and non-infected. Expression of placenta-related microRNAs in microparticles was analysed by qPCR and the effect of circulating microparticles on dendritic cells assessed by phenotype analysis and cytokine/chemokine measurement.Results:
Concentrations of total and trophoblast microparticles detected by flow cytometry were higher in HIV-positive (P = 0.005 and P = 0.030, respectively) compared to non-infected mothers, as well as in women delivering low birthweight newborns (P = 0.032 and P = 0.021, respectively). miR-517c was overexpressed in mothers with placental malaria (P = 0.034), compared to non-infected. Microparticles from HIV-positive induced a higher expression of MHCII (P = 0.021) and lower production of MCP1 (P = 0.008) than microparticles from non-infected women.Conclusions:
In summary, alterations in total and trophoblast microparticles associated with malaria and HIV in pregnant women may have an immunopathogenic role. The potential for placental-derived vesicles and microRNAs as biomarkers of adverse outcomes during pregnancy and malaria infection should be confirmed in future studies.Palavras-chave
Texto completo:
1
Base de dados:
RSDM
Assunto principal:
Placenta
/
Plasmodium falciparum
/
Malária Falciparum
/
MicroRNAs
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article