Lacticaseibacillus casei decrease long-chain fatty acids and most substances in an experimental model of intestinal mucositis
Acta cir. bras
; 38: e386723, 2023. tab, graf, ilus
Article
em En
| LILACS, VETINDEX
| ID: biblio-1527586
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Purpose:
To evaluate the long-chain fatty acid and major compounds levels in the feces after prophylactic oral use of Lacticaseibacillus casei in an experimental model of intestinal mucositis.Methods:
Fifteen Swiss mice were randomly divided into three groups (n=5/group) The negative or positive control groups (n = 5) received saline orally for 18 days and an the intraperitoneal (i.p.) of saline or 5 Fluorouracil (450 mg/kg) in 15th day, respectability. L. casei group received oral concentration of L. casei (1x109 CFU/mL) for 18 days, the i.p. injection of 5-fluorouracil (450 mg/kg) in 15th days. Tissue samples from colon and each small intestine segment were collected for histopathological analysis. Stool samples were collected. Fecal composition of long-chain fatty acids and sterols were analysed by gas chromatography-mass spectrometry on the 15th and the 18th day.Results:
The mucosa layer of all small intestine segments of animals from L. casei showed well preserved epithelium and glands, without necrosis signs, but Goblet cells number decreased. Several long-chain fatty acids and sterols have been identified before and after in the groups. L. casei administration after 5-FU treatment reduced concentrations of linoleic acid (182) (p < 0.001) and oleic acid (181) (p < 0.001) in feces.Conclusions:
L. casei prevented the mucosal damage associated with 5-FU-induced intestinal mucositis reduced long-chain fatty acid levels in the feces.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
/
VETINDEX
Assunto principal:
Doenças Inflamatórias Intestinais
/
Mucosite
/
Ácidos Graxos
/
Lacticaseibacillus casei
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article