Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity
Farias, Leonardo Paiva; Chalmers, Iain W.; Perally, Samirah; Rofatto, Henrique Krambeck; Jackson, Colin J.; Brown, Martha; Khouri, Mariana I.; Barbosa, Mayra Mara Ferrari; Hensbergen, Paul J.; Hokke, Cornelis H.; Leite, Luciana Cezar de Cerqueira; Hoffmann, Karl F..
Int J Parasitol, v. 49, n. 8, p. 593-599, jul. 2019
Artigo
Inglês
| SES-SP, SES SP - Instituto Butantan, SES-SP | ID: bud-2793
Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A–D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.
Biblioteca responsável:
BR78.1
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