Background By the fact that pregnant and
postpartum women are currently using
COVID-19 vaccines, ensure their
safety is critical. So, more
safety evidence is crucial to include this new
technology to their
vaccine’s calendar and to develop
public policies regarding the support and
training of
Health Care Personnel. This study aims to describe the adverse events (AE) of
COVID-19 vaccines in pregnant and
postpartum women in the early stage of
vaccination campaign in
Brazil.
Methods An observational
cross-sectional study using data from the Brazilian
surveillance information system to characterize the AE of
COVID-19 vaccines (Sinovac/Butantan, Pfizer/BioNTech, AstraZeneca and Janssen) in Brazilian pregnant and
postpartum women from April to August 2021. Frequency and
incidence rate of AE for
COVID-19 vaccines were assessed. Results 3,333 AE following
immunization were reported for the study
population. AE
incidence was 309.4/100,000 doses (95% CI 297.23, 321.51). Within the
vaccines available, Sinovac/Butantan had the lowest
incidence (74.08/100,000 doses; 95% CI 63.47, 84.69). Systemic events were the most frequent notified (82.07%), followed by local (11.93%) and maternal (4.74%), being most of them classified as non-severe (90.65%). Conclusion Our results corroborate the recommendation of
vaccination for these groups. Even though, further studies appraising a longer
observation time are still needed to provide a broader
safety aspect for the
vaccines currently under use for this
population.