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Cancer associated autoantibodies in idiopathic inflammatory myopathies: A retrospective cohort from a single center in China
Zhao, Yin; Su, Haiyuan; Yin, Xiaoyang; Hou, Hou; Wang, Ying’a; Xu, Yong; Li, Xin; Zhang, Nang; Sun, Wenwen; Wei, Wei.
Afiliação
  • Zhao, Yin; Tianjin Medical University General Hospital. Tianjin. China
  • Su, Haiyuan; Tianjin Medical University General Hospital. Tianjin. China
  • Yin, Xiaoyang; Tianjin Medical University General Hospital. Tianjin. China
  • Hou, Hou; Tianjin Medical University General Hospital. Tianjin. China
  • Wang, Ying’a; Tianjin Medical University General Hospital. Tianjin. China
  • Xu, Yong; Tianjin Medical University General Hospital. Tianjin. China
  • Li, Xin; Tianjin Medical University General Hospital. Tianjin. China
  • Zhang, Nang; Tianjin Medical University General Hospital. Tianjin. China
  • Sun, Wenwen; Tianjin Medical University General Hospital. Tianjin. China
  • Wei, Wei; Tianjin Medical University General Hospital. Tianjin. China
Med. clín (Ed. impr.) ; 160(1): 10-16, enero 2023. tab, graf
Article em En | IBECS | ID: ibc-213902
Biblioteca responsável: ES1.1
Localização: ES15.1 - BNCS
ABSTRACT

Objectives:

Idiopathic inflammatory myopathies (IIMs) are systemic, heterogeneous diseases, which mainly affect skeletal muscle. Myositis with cancer is often referred to as cancer-associated myositis (CAM), which is associated with poor prognosis. This study aimed to determine the cancer associated myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with IIMs.MethodsThis retrospective study enrolled 312 patients with IIMs who were treated at Tianjin Medical University General Hospital, China, from January 2015 to December 2020. Clinical data were collected. Serum MSAs, including anti-Mi-2, anti-TIF1-γ, anti-NXP2, anti-SAE, anti-MDA5, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-OJ, anti-EJ and anti-HMGCR antibodies were detected. Cancer-associated MSAs, their phenotypic and survival features were estimated through SPSS 20.0.ResultsThe results revealed that anti-TIF1-γ antibody and anti-SAE antibody were cancer-associated autoantibodies with odds ratios (95% CI) of 8.70 (3.35–22.64) and 22.31 (4.32–115.05), respectively. Skin lesions, proximal weakness, dysphagia and dysarthria were observed more frequently in patients carrying anti-TIF1-γ antibody. By contrast, patients with anti-TIF1-γ antibody had a lower frequencies of fever, arthritis/arthralgia and interstitial lung disease (ILD). Anti-TIF1-γ antibody positive CAM comprised about half of CAM entities and had the characteristic of close temporal association with cancer detection/recurrence. Female-dominant, common reproductive system tumors were other clinical features of this subset. Besides, patients with anti-TIF1-γ antibody positive had significantly lower survival rates than the anti-TIF1-γ antibody negative group. (AU)
RESUMEN

Objetivo:

La miopatía inflamatoria idiopática (IIM, por sus siglas en inglés) es una enfermedad sistémica y heterogénea que afecta principalmente al músculo esquelético. La miositis asociada al cáncer se denomina a menudo miositis relacionada con el cáncer, y está relacionada con un mal pronóstico. El objetivo de este estudio fue identificar autoanticuerpos específicos de miositis relacionados con el cáncer en pacientes chinos, y dilucidar su correlación con las características clínicas.MétodosEl estudio retrospectivo incluyó a 312 pacientes con IIM tratados en el hospital general de la Universidad Médica de Tianjin, China, de enero de 2015 a diciembre de 2020. Recoger datos clínicos. Se detectaron autoanticuerpos específicos de miositis sérica, incluyendo anti-Mi-2, anti-TIF1-γ, anti-NXP2, anti-SAE, anti-MDA5, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-OJ, anti-EJ, anti-HMGCR. Los autoanticuerpos relacionados con el cáncer, sus fenotipos y sus características de supervivencia fueron evaluados por SPSS® 20.0.ResultadosLos resultados mostraron que el anticuerpo anti-TIF1-γ y el anticuerpo anti-SAE eran autoanticuerpos relacionados con el cáncer con una relación de predominio (IC 95%) de 8,70 (3,35–22,64) y 22,31 (4,32–115,05), respectivamente. La frecuencia de lesiones cutáneas, debilidad proximal, disfagia y disartria fue mayor en los pacientes portadores de anticuerpos anti-TIF1-γ. En comparación, la incidencia de fiebre, artritis/artralgia y enfermedad pulmonar intersticial (ILD) en pacientes con anticuerpos anti-TIF1-γ fue menor. La miositis relacionada con el cáncer con anticuerpos anti-TIF1-γ positivos representa aproximadamente la mitad de la miositis relacionada con el cáncer y tiene características temporales estrechamente relacionadas con la detección/recidiva del cáncer. (AU)
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Base de dados: IBECS Assunto principal: Autoanticorpos / Miosite / Neoplasias Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Buscar no Google
Base de dados: IBECS Assunto principal: Autoanticorpos / Miosite / Neoplasias Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2023 Tipo de documento: Article