Hereditary spastic paraplegia associated with thin corpus callosum
Arq. neuropsiquiatr
; 59(3B): 790-792, Sept. 2001. ilus
Article
em En
| LILACS
| ID: lil-295850
Biblioteca responsável:
BR1.1
ABSTRACT
Autosomal recessive hereditary spastic paraplegia (AR-HSP) associated with thin corpus callosum was recently described in Japan, and most families were linked to chromosome 15q13-15. We report two patients from two different Brazilian families with progressive gait disturbance starting at the second decade of life, spastic paraparesis, and mental deterioration. One patient presented cerebellar ataxia. Magnetic resonance imaging (MRI) of the head of both patients showed a thin corpus callosum. AR-HSP with a thin corpus callosum is a rare disorder, mainly described in Japanese patients. We found only 4 Caucasian families with AR-HSP with thin corpus callosum described in the literature. Further studies including additional Caucasian families of AR-HSP with thin corpus callosum are required to delineate the genetic profile of this syndrome in occidental countries
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Paraplegia Espástica Hereditária
/
Corpo Caloso
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Female
/
Humans
/
Male
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article