Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice
Braz. j. med. biol. res
; 36(4): 521-524, Apr. 2003. tab
Article
em En
| LILACS
| ID: lil-331230
Biblioteca responsável:
BR1.1
ABSTRACT
We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; N = 8-10, P<0.05) of acetic acid-induced writhing, causing up to a 60 percent inhibition at the highest dose used, comparable to that obtained with indomethacin (10 mg/kg, po). At the same doses, EOOG predominantly inhibited the late (inflammatory) phase of the formalin-induced pain response (from 59.3 ± 8.3 to 40.4 ± 4.8, 23.2 ± 2.8 and 25.3 ± 5.5, respectively; N = 6, P<0.05), with a maximal reduction of 60 percent of the control, although a significant reduction of the initial (neurogenic) phase was also observed at 300 mg/kg (from 62.5 ± 6.07 to 37 ± 5.9; P<0.05). On the basis of these data, we conclude that EOOG possesses interesting antinociceptive properties in the writhing and formalin tests. Due to the relatively low toxicity of EOOG, further detailed examination is strongly indicated for a better characterization of its pharmacological properties and its potential therapeutic value
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Medição da Dor
/
Óleos Voláteis
/
Lamiaceae
/
Analgésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article