(TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
Genet. mol. biol
; 27(3): 335-336, Sept. 2004. tab
Article
em En
| LILACS
| ID: lil-366176
Biblioteca responsável:
BR26.1
ABSTRACT
We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1), 0.021 and 0.04. In addition, one Euro-Brazilian individual had a rare allele with 13 repeats. The allelic frequencies in Euro- and Afro-Brazilians differed statistically (p < 10-3). The two samples were found to be in Hardy-Weinberg equilibrium (p = 0,828 and p = 0,995).
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
/
Neoplasias da Mama
/
Aromatase
Limite:
Humans
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article