Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians

ABSTRACT

The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missão Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0 percent for GSTM1 and 27 percent for GSTT1 while for the Kayabi sample the null phenotype frequencies were 27 percent for GSTM1 and 29 percent for GSTT1. This is the first report of the absence of the GSTM1 null phenotype in any ethnic group.