Nuevo modelo experimental de Estenosis Valvular Aórtica / New experimental model of aortic valve stenosis in rabbits

ABSTRACT

Aortic valve stenosis is a chronic progressive disease, being the most common type of valvular disease in developed countries. Despite its increasing incidence, both molecular and celular mechanisms of the disorder have not been adequately determined, in part because of lack of appropriate experimental models. This study was designed to assay an experimental new model of aortic valve stenosis in hypertensive rabbits which could be useful to study the early evolution of the disease, and also to test different pharmacological treatments to prevent its progression