HIV subtype, epidemiological and mutational correlations in patients from Paraná, Brazil
Braz. j. infect. dis
; 14(5): 495-501, Sept.-Oct. 2010. ilus, tab
Article
em En
| LILACS
| ID: lil-570565
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
Analyze patients with HIV infection from Curitiba, Paraná, their epidemiological characteristics and HIV RAM.METHODS:
Patients regularly followed in an ID Clinic had their medical data evaluated and cases of virological failure were analyzed with genotypic report.RESULTS:
Patients with complete medical charts were selected (n = 191). Demographic and clinical characteristics were compared. One hundred thirty two patients presented with subtype B infection (69.1 percent), 41 subtype C (21.5 percent), 10 subtype F (5.2 percent), 7 BF (3.7 percent) and 1 CF (0.5 percent). Patients with subtype B infection had been diagnosed earlier than patients with subtype non-B. Also, subtype B infection was more frequent in men who have sex with men, while non-B subtypes occurred more frequently in heterosexuals and women. Patients with previous history of three classes of ARVs (n = 161) intake were selected to evaluate resistance. For RT inhibitors, 41L and 210W were more frequently observed in subtype B than in non-B strains. No differences between subtypes and mutations were observed to NNTRIs. Mutations at 10, 32 and 63 position of protease were more observed in subtype B viruses than non-B, while positions 20 and 36 of showed more amino acid substitutions in subtype non-B viruses. Patients with history of NFV intake were evaluated to resistance pathway. The 90M pathway was more frequent in subtypes B and non-B. Mutations previously reported as common in non-B viruses, such as 65R and 106M, were uncommon in our study. Mutations 63P and 36I, previously reported as common in HIV-1 subtypes B and C from Brazil, respectively, were common.CONCLUSION:
There is a significant frequency of HIV-1 non-B infections in Paraná state, with isolates classified as subtypes C, F, BF and BC. Patients with subtype C infection were more frequently female, heterosexual and had a longer average time of HIV diagnosis.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Infecções por HIV
/
HIV-1
/
HIV
/
Mutação
Limite:
Adult
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Female
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Humans
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Male
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article