The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population
Genet. mol. biol
; 33(4): 610-614, 2010. tab
Article
em En
| LILACS
| ID: lil-571528
Biblioteca responsável:
BR1.1
ABSTRACT
The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR 3.22, 95 percentCI 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR 4.32, 95 percentCI 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.
Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
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Ativação Transcricional
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Genes p53
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Genes p16
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Proteínas Proto-Oncogênicas c-mdm2
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article
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Project document