Variación de alelos del gen receptor de dopamina DRD4 en escolares chilenos de diferente origen étnico y su relación con riesgo de déficit atencional/hiperactividad / DRD4 dopamine receptor alleles in Chilean students of different ethnic origin and its relation with the risk for attention deficit/hyperactivity disorder
Rev. méd. Chile
; 140(10): 1276-1281, oct. 2012. tab
Article
em Es
| LILACS
| ID: lil-668700
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Worldwide diversity of alleles of D4 receptor gene (DRD4), linked to attention deficit hyperactivity disorder (ADHD), is mostly the result of length and single nucleotide polymorphisms in a 48-bp tandem repeat (VNTR). Alleles containing from two (2R) to eleven (11R) repeats have been identified. The most common are 4R, 7R and 2R.Aim:
To study the association of ADHD risk with DRD4 genotypes in Chilean students. Subjects andMethods:
ADHD risk data were obtained through the abbreviated Conner's Scale for School Teachers in 66 Aymara children (11 cases and 55 controls), 91 Rapa-Nui children (60 cases ad 31 controls) and 96 children from a mixed urban population from Santiago (51 cases and 45 controls). DNA extracted from saliva was amplified by polymerase chain reaction (PCR) to genotype the DRD4 VNTR.Results:
The distribution of DRD4 alleles reveals that, beneath the 4R allele, 7R exhibits the second highest frequencies in Aymara and Santiago children. In Polynesian children, 2R ranks after 4R. A statistically significant association between ADHD risk and 2R/4R genotype was identified in Polynesian children (p < 0.05; odds ratio = 3.7).Conclusions:
Different DRD4 genotypes are associated with ADHDphenotype in Chilean populations, probably as a consequence of their initial colonization history.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
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Indígenas Sul-Americanos
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Dopamina
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Humans
País como assunto:
America do sul
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Chile
Idioma:
Es
Ano de publicação:
2012
Tipo de documento:
Article
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Project document