Association between the c.910A>G genetic variant of the XRCC1 gene and susceptibility to esophageal cancer in the Chinese Han population
Braz. j. med. biol. res
; 46(12): 1028-1032, dez. 2013. tab
Article
em En
| LILACS
| ID: lil-695983
Biblioteca responsável:
BR1.1
ABSTRACT
Esophageal cancer (EC) is a common malignancy worldwide. The X-ray repair cross-complementing 1 gene (XRCC1) is one of the most important candidate genes for influencing susceptibility to EC. This study aimed to investigate the effect of XRCC1 genetic variants on susceptibility to EC. A total of 383 EC patients (males 239, females 144, mean age 56.62) and 387 cancer-free controls (males 251, females 136, mean age 58.23) were enrolled in this study. The c.910A>G genetic variant of the XRCC1 gene was determined by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. The allele and genotype frequencies indicated statistical differences between EC patients and cancer-free controls. The c.910A>G genetic variant was statistically associated with increased susceptibility to EC [GG vs AA odds ratio (OR)=1.79, 95% confidence interval (CI)=1.12-2.86, P=0.014; GG vs AG/AA OR=1.76, 95%CI=1.13-2.75, P=0.013; G vs A OR=1.25, 95%CI=1.01-1.55, P=0.041]. The allele G and genotype GG could contribute to the increased susceptibility to EC. Our findings suggest that the c.910A>G genetic variant is associated with susceptibility to EC in the Chinese Han population, and might be used as a molecular marker for detecting susceptibility to EC.
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Base de dados:
LILACS
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article