In vivo assessment of antiretroviral therapy-associated side effects
Mem. Inst. Oswaldo Cruz
; 109(4): 484-487, 03/07/2014. tab, graf
Article
em En
| LILACS
| ID: lil-716314
Biblioteca responsável:
BR1.1
ABSTRACT
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Gorduras na Dieta
/
Inibidores da Protease de HIV
/
Indinavir
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article