Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
Acta cir. bras
; Acta cir. bras;31(3): 190-197, Mar. 2016. tab, graf
Article
em En
| LILACS
| ID: lil-777097
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI).METHODS:
Male Wistar rats underwent ligation of the left coronary artery and divided into three groups MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups.RESULTS:
Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium.CONCLUSION:
Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.Palavras-chave
Texto completo:
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Base de dados:
LILACS
Assunto principal:
Óleos de Plantas
/
Ácido gama-Linolênico
/
Remodelação Ventricular
/
Ventrículos do Coração
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Anti-Inflamatórios
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Infarto do Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article