Regulation of chamber-specific gene expression in the developing heart by Irx4.
Science
; 283(5405): 1161-4, 1999 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-10024241
ABSTRACT
The vertebrate heart consists of two types of chambers, the atria and the ventricles, which differ in their contractile and electrophysiological properties. Little is known of the molecular mechanisms by which these chambers are specified during embryogenesis. Here a chicken iroquois-related homeobox gene, Irx4, was identified that has a ventricle-restricted expression pattern at all stages of heart development. Irx4 protein was shown to regulate the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (VMHC1) and suppressing the expression of the atrial myosin heavy chain-1 (AMHC1) in the ventricles. Thus, Irx4 may play a critical role in establishing chamber-specific gene expression in the developing heart.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Miosinas
/
Proteínas de Homeodomínio
/
Regulação da Expressão Gênica no Desenvolvimento
/
Miosinas Atriais
/
Proteínas Aviárias
/
Átrios do Coração
/
Ventrículos do Coração
/
Proteínas Musculares
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article