[The influence of insulin, glucose and other monosaccharides on the platelet functions (author's transl)]. / Einfluss von Insulin, Glukose und anderen Monosacchariden auf Plättchenfunktionen
Klin Wochenschr
; 54(23): 1137-41, 1976 Dec 01.
Article
em De
| MEDLINE
| ID: mdl-1003872
ABSTRACT
In vitro investigations were carried out on the action of insulin, glucose, xylose, galactose, fructose and sorbitol on the platelet aggregation test according to Breddin, on the ADP- and collagen-inducced aggregation and the release of platelet factor 4 as well as on the retraction. When incubating platelet-rich plasma with insulin and glucose simultaneously, a marked inhibition of the ADP- or collagen-induced platelet aggregation and release reaction results. Insulin as well as glucose impaired the platelet function only at high concentrations, this inhibition however did not reach that of a combination of both. Fructose, xylose and sorbitol exerted no significant inhibitory effects. In contrast to the prevented aggregation, the retraction was enhanced. As the causal mechanism for the inhibition of the platelet function the Crabtree effect is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Glucose
/
Insulina
/
Monossacarídeos
Idioma:
De
Ano de publicação:
1976
Tipo de documento:
Article