Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens.
Science
; 194(4272): 1434-6, 1976 Dec 24.
Article
em En
| MEDLINE
| ID: mdl-1006310
ABSTRACT
Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.
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Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Replicação do DNA
/
Metais
/
Mutagênicos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article