Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives.
Acta Pol Pharm
; 55(6): 487-98, 1998.
Article
em En
| MEDLINE
| ID: mdl-10073136
ABSTRACT
A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of S-(+)-2-amino-1-butanol derivative VIII, which displayed anti-MES activity with a protective index (TD50/ED50) of 4.55 corresponding with that for phenytoin, carbamazepine and valproate.
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Base de dados:
MEDLINE
Assunto principal:
Amino Álcoois
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article