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Neonatal 24-hour urinary C-peptide and birth weight in infants of diabetic mothers.
Sameshima, H; Kamitomo, M; Ibara, S; Kajiya, S; Kai, M; Ikenoue, T.
Afiliação
  • Sameshima H; Perinatal Center and Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake, Japan.
J Matern Fetal Med ; 8(2): 57-60, 1999.
Article em En | MEDLINE | ID: mdl-10090492
OBJECTIVE: Our purpose was to investigate the relationship between the birth weights and 24-h urinary C-peptide in infants of diabetic mothers. METHODS: Sixty pregnancies with gestational diabetes mellitus (DM) were enrolled. Neonatal urine was collected for the first and second 24 h for measuring C-peptide. Birth weights were classified into 3 categories according to the Japanese standard curves; heavy-for-date (HFD), appropriate-for-date (AFD), and light-for-date (LFD). Unpaired t-test was used for comparison of 24-h urinary C-peptide in the 3 birth weight categories, with P-value <0.05. There were 7 HFD, 47 AFD, and 6 LFD infants. Birth weight averaged 3.9+/-0.7, 3.0+/-0.4, and 2.3+/-0.3 kg, respectively. RESULTS: Insulin concentrations of the umbilical artery were significantly higher in HFD than in AFD, and significantly higher in AFD than in LFD (49.5+/-45.1, 16.8+/-15.2, and 6.3+/-6.1 microU/ml). During the first 24 h, urinary C-peptide was significantly higher in HFD than in AFD (2.73+/-1.52 vs. 0.76+/-0.81 microg/day), and significantly higher in AFD than in LFD (0.27+/-0.27). On the second day, there was no longer statistical significance. CONCLUSIONS: Measurement of 24-h urinary C-peptide revealed that, among infants of diabetic mothers, HFD infants continue to secrete more insulin than AFD and LFD infants for the first 24 h.
Assuntos
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Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Peptídeo C / Diabetes Gestacional Limite: Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 1999 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Peptídeo C / Diabetes Gestacional Limite: Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 1999 Tipo de documento: Article