Gap-junction-mediated propagation and amplification of cell injury.
Nat Neurosci
; 1(6): 494-500, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-10196547
ABSTRACT
Gap junctions are conductive channels that connect the interiors of coupled cells. We determined whether gap junctions propagate transcellular signals during metabolic stress and whether such signaling exacerbates cell injury. Although overexpression of the human proto-oncogene bcl2 in C6 glioma cells normally increased their resistance to injury, the relative resistance of bcl2+ cells to calcium overload, oxidative stress and metabolic inhibition was compromised when they formed gap junctions with more vulnerable cells. The likelihood of death was in direct proportion to the number and density of gap junctions with their less resistant neighbors. Thus, dying glia killed neighboring cells that would otherwise have escaped injury. This process of glial 'fratricide' may provide a basis for the secondary propagation of brain injury in cerebral ischemia.
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Base de dados:
MEDLINE
Assunto principal:
Junções Comunicantes
/
Estresse Oxidativo
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article