Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations.
Nat Med
; 5(5): 526-34, 1999 May.
Article
em En
| MEDLINE
| ID: mdl-10229229
ABSTRACT
Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Infecções por Lentivirus
/
Vacinação
/
Vacinas de DNA
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article