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Long-term renal allograft recipients from South-east Asia in the pre-cyclosporin era.
Tang, S; Lui, S L; Li, F K; Lo, W K; Chan, T M; Lai, K N.
Afiliação
  • Tang S; University Department of Medicine, Queen Mary Hospital, Hong Kong, China.
Int J Artif Organs ; 22(3): 131-7, 1999 Mar.
Article em En | MEDLINE | ID: mdl-10357240
The clinical outcome of long-term renal allograft recipients in the Chinese population has not been reported previously. We analysed patients from the pre-cyclosporin era who had grafts that functioned for > 10 years. Forty-five patients (31 men, 14 women; mean age 30, follow-up duration 13.3 years), representing a 10-year graft survival of 53%, were included. Thirty-six patients (80%) received living-related allografts and 9 (20%) received cadaveric or living-unrelated renal transplantation. The mean serum creatinine at last follow-up was 1.36 mg/dl (range, 0.83-4.08). Major posttransplantation complications included: hypertension in 25 (56%), infection in 16 (36%), acute rejection in 15 (33%), lipid disorder in 13 (29%), liver disease in 7 (16%), osteonecrosis in 5 (11%), malignancy in 4 (9%), coronary artery disease in 3 (7%), and diabetes mellitus in 3 (7%). Five grafts were lost: 3 to chronic rejection, and 2 to patients with stable function who died of non-renal causes. Proteinuria correlated strongly with graft function and survival, and marginally with hypertension. In hepatitis B carriers, serum alpha-feto protein is useful in the early detection of hepatocellular carcinoma. We conclude that while patients in the pre-cyclosporin era can survive with excellent graft function beyond the first decade, the risk of complications leading to significant morbidity still remains even when patients are receiving minimal doses of immunosuppression in the second decade.
Assuntos
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Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Imunologia de Transplantes / Transplante de Rim / Ciclosporinas / Imunossupressores / Falência Renal Crônica Tipo de estudo: Diagnostic_studies / Etiology_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged / Pregnancy País como assunto: Asia Idioma: En Ano de publicação: 1999 Tipo de documento: Article
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Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Imunologia de Transplantes / Transplante de Rim / Ciclosporinas / Imunossupressores / Falência Renal Crônica Tipo de estudo: Diagnostic_studies / Etiology_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged / Pregnancy País como assunto: Asia Idioma: En Ano de publicação: 1999 Tipo de documento: Article