The roles of RNA-binding proteins in spermatogenesis and male infertility.
Curr Opin Genet Dev
; 9(3): 346-54, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10377282
ABSTRACT
RNA-binding proteins are essential for spermatogenesis they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.
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Base de dados:
MEDLINE
Assunto principal:
Espermatogênese
/
Proteínas de Ligação a RNA
/
Infertilidade Masculina
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article