Pharmacological evaluation of an in vivo model of vestibular dysfunction in the rat.
Methods Find Exp Clin Pharmacol
; 21(4): 285-9, 1999 May.
Article
em En
| MEDLINE
| ID: mdl-10399137
ABSTRACT
A unilateral microinjection of either histamine or kainic acid was made into the medial vestibular nucleus of rats, eliciting robust barrel rotations that were evaluated by an elevated body-rotation test. Systemic pretreatment with betahistine or GT-2016 significantly attenuated the kainic acid-induced barrel rotations. These data indicate that the animal model described herein may represent a new model to identify novel drugs with potential antivertigo properties.
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Base de dados:
MEDLINE
Assunto principal:
Núcleos Vestibulares
/
Histamina
/
Doenças Vestibulares
/
Modelos Animais de Doenças
/
Ácido Caínico
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article