Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
Science
; 285(5428): 736-9, 1999 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-10426996
ABSTRACT
Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Glicoproteínas de Membrana
/
Monócitos
/
Apoptose
/
Receptores de Superfície Celular
/
Proteínas de Drosophila
/
Lipoproteínas
Limite:
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article