Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent.

Chun, M W; Choi, S P; Kim, M J; Bae, C J; Moon, H R; Kim, H D; Jeong, L S

Chun, M W; Choi, S P; Kim, M J; Bae, C J; Moon, H R; Kim, H D; Jeong, L S.

Afiliação

Chun MW; College of Pharmacy, Seoul National University, Korea.

Nucleosides Nucleotides ; 18(4-5): 615-6, 1999.

Article em En | MEDLINE | ID: mdl-10432654

RESUMO

Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from D-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV.

Assuntos

Antivirais/síntese química; Antivirais/farmacologia; Nucleosídeos/síntese química; Nucleosídeos/farmacologia; HIV-1/efeitos dos fármacos; Herpesviridae/efeitos dos fármacos; Testes de Sensibilidade Microbiana

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