A characterization of vitamin D-independent intestinal calcium absorption in the osteopetrotic (op/op) mouse.
Arch Biochem Biophys
; 368(2): 249-56, 1999 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-10441375
ABSTRACT
Previous work in our laboratory showed that the osteopetrotic (op/op) mouse possesses a vitamin D-independent mechanism of intestinal calcium absorption. This study was performed in an effort to further characterize the mechanism. The vitamin D-deficient op/op mouse absorbed calcium faster than either a vitamin D-deficient or 1, 25-dihydroxyvitamin D(3)-supplemented wild-type mouse. This increased rate of absorption was not found at concentrations of calcium that result in diffusional calcium absorption. Thus, vitamin D-deficient op/op mice had intestinal calcium absorption similar to that of vitamin D-deficient wild-type littermates when increasing levels of calcium were administered. Also, mRNA and protein levels of calbindin-D9k were similar in vitamin D-deficient wild-type and op/op mice as well as in wild-type and op/op mice treated with 1, 25-dihydroxyvitamin D(3). Therefore, the mechanism of vitamin D-independent intestinal calcium absorption in the op/op mouse is distinct from vitamin D-dependent intestinal calcium absorption.
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Base de dados:
MEDLINE
Assunto principal:
Osteopetrose
/
Deficiência de Vitamina D
/
Cálcio
/
Mucosa Intestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article