HFE gene mutation and transferrin saturation in very low birthweight infants.
Arch Dis Child Fetal Neonatal Ed
; 81(2): F144-5, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10448186
ABSTRACT
AIM:
To determine if there is an association between high transferrin saturation and the C282Y HFE gene mutation in very low birthweight (VLBW) infants.METHODS:
One hundred and forty three VLBW infants receiving recombinant erythropoietin and 3 to 9 mg/kg/day of enteral iron were studied. Genomic DNA was extracted from filter paper cards. The C282Y mutation was determined by restriction fragment length polymorphism analysis.RESULTS:
Six infants were heterozygous for the mutation; none was homozygous. Ten infants had a transferrin saturation above 80% at least once. No infant was positive for both transferrin saturation above 80% and the mutation.CONCLUSIONS:
The data strongly suggest that there is no association between high transferrin saturation and the HFE gene mutation in VLBW infants during the first weeks of life.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transferrina
/
Antígenos de Histocompatibilidade Classe I
/
Recém-Nascido de muito Baixo Peso
/
Antígenos HLA
/
Proteínas de Membrana
/
Mutação
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article