Novel canine tumour suppressor gene p53 mutations in cases of skin and mammary neoplasms.
Vet Res Commun
; 23(5): 285-91, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10493115
ABSTRACT
Exons 4 to 8 of the tumour suppressor gene p53 were analysed in 25 skin and 25 mammary tumours of 50 dogs. A 1 bp deletion (ACC-->AC) was detected in codon 89 in exon 4 in a squamous cell carcinoma. A missense mutation CGC-->CAC (arginine-->histidine) was present in codon 162 in exon 5 in a mammary adenocarcinoma. Moreover, a silent mutation occurred in codon 103 (serine) of exon 4 in a mammary adenoma. The somatic nature of the three mutations was demonstrated.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Neoplasias Mamárias Animais
/
Genes p53
/
Doenças do Cão
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article