The Sydney Blood Bank Cohort: a case-control study using a transfused HIV-1 seronegative group.
Ann Epidemiol
; 9(7): 436-40, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10501411
ABSTRACT
PURPOSE:
To compare the immunological function of the Sydney Blood Bank Cohort (SBBC), a unique group of individuals who were all infected with a similar, attenuated strain of HIV-1, with a matched HIV-1 seronegative control group. To establish whether the asymptomatic state of the SBBC, in 1996, was likely to continue, and whether the SBBC were free from immunological signs of disease progression.METHODS:
A prospective case-control design using a matched transfused HIV-1 seronegative control group. Immunological testing was performed and compared across the groups. These measurements included CD4+, CD8+, CD3 + subsets, total lymphocytes, beta-2-microgloublin (beta2M), and neopterin.RESULTS:
Significant differences were observed between the SBBC and the controls, particularly CD4% (p < 0.05), CD8 counts (p < 0.01), and CD4CD8 ratios (p < 0.001).CONCLUSIONS:
The results suggested that, as a group, the SBBC remained asymptomatic 12 to 16 years after infection with HIV-1. However, elevated CD8+ T lymphocytes, together with decreasing CD4%, suggested that some SBBC members were showing early immunologicalsigns of disease progression during late 1996, confirmed by recent (1998) follow-up studies.
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Base de dados:
MEDLINE
Assunto principal:
Bancos de Sangue
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Soronegatividade para HIV
/
Reação Transfusional
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País como assunto:
Oceania
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article