Pentostatin therapy of T-cell lymphomas with cutaneous manifestations.
J Clin Oncol
; 17(10): 3117-21, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10506607
ABSTRACT
PURPOSE:
To determine the side effects of and response to pentostatin in patients with T-cell lymphomas with cutaneous manifestations. PATIENTS ANDMETHODS:
Pentostatin was administered to 28 patients who had relapsed cutaneous T-cell lymphoma or peripheral T-cell lymphoma with prominent cutaneous disease. The starting dose was between 3.75 to 5.0 mg/m(2)/d intravenous for 3 days every 3 weeks.RESULTS:
Of the 24 patients assessable for response, 17 (71%) achieved a partial remission (46%) or complete remission (25%). The patients had a median number of three (range, one to 12) prior therapies. Of the 86 courses of pentostatin given, 39 were administered at doses of 5.0 mg/m(2)/d and 30 at doses of 3. 75 mg/m(2)/d. Dose escalation to 6.25 mg/m(2)/d was possible in only five courses, and toxicity necessitated dose reduction to 2.8 mg/m(2)/d in 12 courses. The most common side effects were granulocytopenia, nausea, and nonneutropenic fever. Most patients developed significant lowering of CD4 counts. Herpes zoster was seen within 1 year after pentostatin in five patients (19%).CONCLUSION:
Pentostatin is an active agent in heavily pretreated T-cell lymphomas with cutaneous manifestations.
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Base de dados:
MEDLINE
Assunto principal:
Pentostatina
/
Linfoma de Células T
/
Linfoma Cutâneo de Células T
/
Antibióticos Antineoplásicos
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article