Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor.
Bioorg Med Chem Lett
; 9(18): 2715-20, 1999 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-10509922
ABSTRACT
A novel series of 5,6,7,8-tetrahydroquinazolines, 4,5,6,7-tetrahydroindazoles and 4,5,6,7-tetrahydrobenzothiazoles has been prepared, having high affinity and selectivity for the dopamine D3 receptor. The 4-methoxy-5,6,7,8-tetrahydroquinazoline 6i and 2-amino-4,5,6,7-tetrahydrobenzothiazole 8 proved to be agonists with among the highest D3 receptor affinities and selectivities reported to date.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tetra-Hidronaftalenos
/
Receptores de Dopamina D2
/
Compostos Heterocíclicos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article