Early age at menopause and breast cancer: are leaner women more protected? A prospective analysis of the Dutch DOM cohort.
Breast Cancer Res Treat
; 55(3): 285-91, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10517172
ABSTRACT
To investigate the relationship between age at menopause, body mass index, and breast cancer risk, we used data from a prospective cohort study (DOM cohort) in the Netherlands. Participants in this breast cancer-screening project included 10,591 women living in Utrecht, aged 49-66 years at enrolment. During a median follow-up period of 19 years, women attended screening rounds at which anthropometric measurements were taken and questions were asked about menopausal status, age at menopause, medication use and other risk factors for breast cancer. Cox regression analysis was used to investigate the relationship between age at menopause and subsequent breast cancer risk. Breast cancer incidence decreased with an earlier age at menopause. Women with a menopausal age of 44 years or younger had a 34% lower risk of breast cancer, than women with a menopausal age over 54 years (hazard ratio is 0.66 (95% confidence interval 0.43-0.91)). The annual hazard of breast cancer incidence decreased by 2.6% per year reduction in age at menopause. The protective effect of an early age at menopause was stronger for women with a low body mass index (< or = 27 kg/m2; reduction of 44%) than for women with a high body mass index (>27 kg/m2; reduction of 24%), although this difference was not statistically significant (P for interaction = 0.58). This difference was most pronounced in women who had ever smoked. Adjustment for known breast cancer risk factors did not alter the crude risk estimates significantly. In conclusion, this study provides evidence of the protective effect of lower age at menopause on subsequent breast cancer risk. This protective effect may be even stronger in leaner women.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Menopausa
/
Índice de Massa Corporal
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Aged
/
Female
/
Humans
/
Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article